As of September 2026, injectable NAD+ is not approved by the FDA and has no EMA marketing authorisation. It is sold only as a compounded product. The one human study is a small look-back at the records of 14 people, and no randomized trial has been completed. FDA records show recalls for contamination and wrong potency, so a vial can differ from its label in ways you cannot see.
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What is injectable NAD+?
NAD+ is a molecule that every human cell needs for energy and DNA repair, and its levels fall with age. That decline is why injectable NAD+ is marketed with anti-aging and energy claims. Compounding pharmacies prepare it from a bulk chemical, so it has not gone through the FDA trials required of an approved drug.
Does injectable NAD+ work?
Nobody knows. No randomized controlled trial has been completed, and the only human data are one tiny look-back review of how well people tolerated it.
What we found. 0 completed randomized trials. 1 small look-back study of 14 people's records, which does not count because it was not randomized. 1 systematic review of NAD-boosting approaches. 2 recall entries, moved to the legal section.
| Study | Tested in | Status | What it shows |
|---|---|---|---|
| Look-back pilot study of how well NAD+ was tolerated, n=14 | People | Published in 2026. Real-world records | NAD+ was poorly tolerated compared with nicotinamide riboside: cramping, nausea and a fast heart rate. Blood tests stayed largely normal |
| Systematic review of NAD in clinical conditions | People | Published. The literature is mixed | Evidence for NAD-boosting approaches in various clinical conditions remains limited and uncertain |
Neither row is a randomized trial of injectable NAD+.
How we count a trialIs injectable NAD+ safe?
In the one human study, most people given NAD+ had significant discomfort: cramping, nausea, vomiting and a raised heart rate. Their blood tests stayed largely normal. That study covered the records of 14 people, and no randomized trial has established safety. The FDA has also recorded recalls of compounded NAD+ for bacterial endotoxin and for wrong potency. Those are faults in the product, which is where the vial section starts.
Is injectable NAD+ legal?
- United States
- Not approved by the FDA. It is sold only as a compounded product.
- European Union
- No marketing authorisation from the EMA.
- Sport
- Not named on WADA's list. That is not clearance.
- Compounding
- Compounding pharmacies prepare it from a bulk chemical. It has not gone through the FDA trials required of an approved drug.
- Recalls
- The FDA has recorded recalls of compounded NAD+: one in 2022 for potency outside its specification, and one in 2026 for raised endotoxin levels.
Not medical advice. Approval and sport status as of . Medical disclaimer
What is in a vial sold as injectable NAD+?
Injectable NAD+ reaches people as a compounded product, prepared by compounding pharmacies from a bulk chemical. The FDA has recorded recalls of it for potency outside its specification and for raised bacterial endotoxin, a contamination tied to infection risk. A certificate of analysis counts only if it names your lot number, a lab with no stake in the result, and the method used. Purity and identity are separate tests.
Three questions to ask the seller:
- Which lot number is this certificate for?
- Who ran the test, and are they independent of you?
- Does the report confirm identity by mass spectrometry, or purity alone?
What don't we know?
- Whether it does anything for aging or energy. No randomized trial has been completed.
- Whether it is safe. The only human data are the records of 14 people.
- Whether the discomfort seen in that small study would show up in a larger group.
- What is in any given vial. Recalls have found wrong potency and contamination.
The other side
A personal result is real to the person who had it. It cannot separate the compound from the vial, or from the lift that comes with expecting to feel better.
What would change this record?
- A registered, randomized, placebo-controlled human trial of injectable NAD+, large enough to give an answer.
Three questions to ask next
- What does 'research use only' actually mean?
- How can you tell if a peptide vendor is legitimate?
- How do you read a certificate of analysis?
Ask better questions.
More questions about injectable NAD+
Is injectable NAD+ approved by the FDA?
- No. Injectable NAD+ is not an FDA-approved drug, and it has no EMA marketing authorisation. It is sold only as a compounded product.
Has injectable NAD+ been tested in people?
- Only in one small study. It looked back at the records of 14 people and was published in 2026. No randomized controlled trial has been completed.
Has injectable NAD+ been recalled?
- Yes. The FDA has recorded recalls of compounded NAD+: one in 2022 for potency outside its specification and one in 2026 for raised endotoxin levels.
Does injectable NAD+ have side effects?
- In the one human study, yes. Most people given NAD+ had significant discomfort: cramping, nausea, vomiting and a raised heart rate. Their blood tests stayed largely normal. No randomized trial has established its safety.
Is injectable NAD+ banned in sport?
- It is not named on WADA's list. That is not clearance.
Record checked on . Each source shows the date it was checked.
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